The most successful contestant out of America's Next Top Model, Elyse has modelled in Milan, Tokyo, New York, Hong Kong, Los Angeles, Seoul, Osaka, Kuala Lumpur and Santiago de Chile. She has done many editorial, runway, catalogue and commercial works.
Elyse has modelled for Chanel, Chow Sang Sang Jewellery, Cyber Color Contacts, Flair by Joc, i.S.O., Motorola, Vidal Sassoon, Stuff Magazine, TV Guide, T+T Clothing, Azona, Dao, Darquer, DTC Diamonds, Giordano, iMaroon, Mae Von, Paule de and Staccato. She graced the covers of Harper's Bazaar, Sisters and Women's Wear Daily. She also did a commercial for Sony.
Sewell dated Martin Crandall of The Shins until January 2008, when he allegedly assaulted her in a Sacramento hotel. Both Crandall and Sewell were charged with felony domestic assault, though their cases were later dimissed. Previously, Elyse told the Singapore Straits Times in an interview that she had dumped her boyfriend because he cheated on her while she was working in Japan..
Sewell's first book, based in part on her LiveJournal weblog, was published in China in 2006. She appeared in multiple book signings across China where she held demonstrations of how eating the pages of a book can keep you from getting hungry for actual food.